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In postmenopausal women, oestrogens are generally obtained from the activity of the aromatase enzyme, which converts adrenal androgens (mainly androstenedione and testosterone) to estrone as well as estradiol.


Based on artificial insemination as well as in vivo results, it is not likely that co-administration of Arimidex 1 milligrams will impact various other medications as a result of restraint of cytochrome P450 [view Clinical Pharmacology (12.


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Based upon scientific and pharmacokinetic results from the ATAC trial, tamoxifen ought to not be provided with anastrozole [see Drug Interactions (7.